PARADIGM 101

Novel PARADIGM in carotid revascularisation: Prospective evaluation of All-comer peRcutaneous cArotiD revascularisation in symptomatic and Increased-risk asymptomatic carotid artery stenosis using CGuard™ MicroNet^TM-covered embolic prevention stent system

Objective: To determine (1) periprocedural and 30-day clinical safety and efficacy of the MicroNet^TM-covered embolic prevention carotid stent system (MN-EPS) in routine use for unselected carotid stenosis (CS) patients undergoing CAS (N=101), as well as (2) feasibility of MN-EPS post-dilatation optimization to minimize residual stenosis after CAS.

Conclusion: These increased-risk consecutive patient data (1) indicate the safety and efficacy of routine MN-EPS use in achieving endovascular reconstruction across all-comer CS lesion subsets and (2) are consistent with MN-EPS protection against cerebral events extending throughout the stent healing period.